What is Methotrexate?


Methotrexate can be used to induce an abortion in combination with Misoprostol till 7 weeks (after 3 to 7 days you should take 4 tablets of 200 mcg Misoprostol under the tongue). However, Mifepriston (the abortion pill) is more effective, less toxic and has much less side effects than Methotrexate. If a woman has a choice she should always use Mifepriston. Mifepriston is not available in every country (to obtain Mifepriston please go to Women on Web. Methrotrexate is available in the pharmacies of most countries.

Other indications:

Methotrexate is a medicine used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. Methotrexate has been shown to be effective in treating patients with ectopic pregnancy.

Brand names:

Rheumatrex, Trexall

Use to induce an abortion:

An abortion with the combined use of Methotrexate and Misoprostol is more effective than the use of Misoprostol alone. Methotrexate can be administered as an injection in your muscle or orally.

If you can find a doctor to do an injection of methotrexate, you should get 50 mg/m2 of methotrexate intramuscularly followed by 800 micro gm of  misoprostol under the tongue 3-7 days after the methotrexate.

You can also use the metrotrexate orally (75 mg). Most Methotrextate tablets contain 5 or 10 mg that means you will have to swallow quite a lot of tablets. You can also just drink the fluid in the vials that use used for the injections.
3 to 7 days after using methotrexate you have to take Misoprostol 800 micro gm under the tongue for half an hour.

Contraindications and side effects:

Because methotrexate can cause serious liver disease, patients with alcoholism or liver disease should not use it. Do not use alcohol while taking methotrexate!!
Methotrexate can suppress the body's immunity. Therefore, any symptoms of infection should be reported to the doctor. Patients with underlying immune deficiency diseases should not receive methotrexate. A dry, non-productive cough can be a result of a rare lung toxicity.
Methotrexate can be well tolerated, but also can cause severe toxicity which is usually related to the dose taken. The most frequent reactions include mouth sores, stomach upset, and low white blood counts. Methotrexate can cause severe toxicity of the liver and bone marrow, which require regular monitoring with blood testing. It can cause headache and drowsiness, itching, skin rash, dizziness, and hair loss.

Methotrexate is toxic to the embryo and can cause fetal defects in case of an ongoing pregnancy.


One 2 ml vial of 25 mg/ml Methotrexate costs around 40 USD
100 tablets of 2,5 mg Methotrexate costs around 50 USD